By Harry G. Brittain
Even supposing the legit compendia outline a drug substance by way of its id, purity, power, and caliber, they in general don't offer different actual or chemical information, nor do they checklist tools of synthesis or pathways of actual or organic degradation and metabolism. Such details is scattered during the clinical literature and the documents of pharmaceutical laboratories.Edited through the affiliate Director of Analytical examine and improvement for the yankee organization of Pharmaceutical Scientists, Analytical Profiles of Drug components and Excipients brings this data jointly in a single resource. The scope of the sequence has lately been increased to incorporate profiles of excipient fabrics.
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Extra resources for Analytical Profiles of Drug Substances and Excipients, Vol. 28
BRITTAIN with the protein being precipitated by trichloroacetic acid. After filtration of the precipitate, the filtrate is treated with pyridine and acetic anhydride according to the widely used Furth and Hemnann reaction . The resulting yellow solution of the citric acid complex is measured at 428 nm. 2 Spectrophotometry A handbook of food analysis suggested that citric acid is best determined enzymatically . Following the AOAC enzymatic procedure , citric acid is converted by citric lyase to oxaloacetate and acetate.
In the second, the sample is injected into the carrier system through a sampling valve (Flow Injection Analysis, FIA) . The method of elemental analysis uses ion selective electrodes (ISE) for the determination of elements in organic substances. The usual CITRIC ACID 51 decomposition procedures are used, and measurement with the ISE is used as the final step to simplify the determination of the decomposition products. In the determination of carbon, the citric acid is mineralized in a stream of oxygen and volatile decomposition products are passed over a suitable catalyst on which the ca-bon is converted quantitatively into carbon dioxide.
Tiis yields a more distinct end-point, and its use is preferable to that of phcnolphthalein. 05 mg of the monohydrate. 1 Methods of the United States and Indonesian Pharmacopoeias Both the Indonesian Pharmacopcseia 1995 [ 101 and the Unites States Pharmacopoeia 24  use the scimeprocedure. About 3 g of citric acid (accurately weighed) is dissolvec in 40 mL of water, phenolphthalein TS is added, and the resulting solution is titrated with 1 N sodium hydroxide to a pink end-point. 5 g of citric acid sample is accurately weighed and dissolved in 40 mL sf freshly boiled and cooled water.
Analytical Profiles of Drug Substances and Excipients, Vol. 28 by Harry G. Brittain